Vancomycin Dosing by Patient Renal Function
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| VANCOMYCIN DOSING BY PATIENT RENAL FUNCTION |
|
Therapeutic Levels: |
Peak = 10 to 30 mcg/ml |
| Trough = 5 to 10 mcg/ml | |
|
Loading Dose: |
15-20 mg/kg total body weight(TBW) |
|
Maintenance Dose: |
12-15 mg/kg TBW to be given each interval as defined by the patient's calculated creatine clearance (CICr): |
|
CICr (ml/min) |
Dosing Interval (hours) |
|
>100 |
12 |
| 80-100 | 18 |
| 60-79 | 24 |
| 50-59 | 30 |
| 40-49 | 36 |
| 30-39 | 48 |
| 20-29 | 72 |
| 10-19 | 96 |
| <10 | * |
| *This dosing method may not be optimal for patients with CICr <10 ml/min. Dosing for these patients should be assisted by measured serum concentrations. |