Cidofovir

Nephrotoxicity; Neutropenia

Nephrotoxicity

  • Renal impairment is the major toxicity of cidofovir.
  • Cases of acute renal failure resulting in dialysis and/or contributing to death have occurred with as few as one or two doses of the drug.
  • To reduce possible nephrotoxicity, intravenous prehydration (normal saline) and administration of probenecid must be used prior to each infusion of cidofovir.
  • Renal function (serum creatinine and urine protein) must be monitored within 48 hrs prior to each dose and the dose should be monitored for changes in renal function as appopriate [See Dosage and Administration] (see monitoring recommendations).
  • Contraindicated in patients receiving other nephrotoxic agents.

Neutropenia

  • Neutropenia has been observed in assoication with cidofovir treatment
  • Neutrophil counts should eb monitored during cidofovir therapy

Indications

  • Cidofovir is indicated only for treatment of CMV retinitis in patients with AIDS

Animal Data

  • In animal studies, cidofovir was carcinogenic, teratogenic, and caused hypospermia

Monitoring data

  • Serum creatinine and urine protein monitored within 48 hours prior to each dose. Dose adjustment required for changes in renal functions.
  • Neutrophils counts should be monitored during therapy.

Patient counseling

Package inserts

Additional information

Updated: January 2018